- SC - Subscriber Connector or Standard Connector or Square Connector (View)
- SCP - System Code Processor
- SCSI - Small Computer System Interface
- SDLC - Software Development Life Cycle
- SDRAM - Synchronous/Static Dynamic Random Access Memory
- SIM - Subscriber Identity Module or Subscriber Identification Module
- SIMM - Single In-line Memory Module
- SMA - Screw Mounted Adapter
- SMPS - Switch Mode Power Supply
- SMTP - Simple Mail Transfer Protocol
- SNA - Systems Network Architecture
- SNOBOL - StriNg Oriented symBOlic Language
- SPX - Sequenced Packet Exchange
- SQL - Structured Query Language
- SRAM - Static RAM
- SSDD - Single Sided Double Density
- SSHD - Single Sided High Density
- SSI - Single Scale Integration
- SSSD - Single Sided Single Density
- ST - Straight Tip (View)
- STD - Standard Trunk Dialing
- STP - Shielded Twisted Pair
- SVGA - Super Video Graphics Array / Adapter
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