- DARPA - Defense Advanced Research Project Agency
- DBMS - Database Management System
- DC - Direct Current
- DCU - Device Control Unit
- DDoS - Distributed Denial-of-Service (View)
- DEA - Data Encryption Algorithm
- DES - Data Encryption Standard
- DIMM - Double In-line Memory Module
- DIX - DEC-Intel-Xerox (connector)
- DHCP - Dynamic Host Configuration Protocol
- DNA - Deoxyribo Nucleic Acid
- DNS - Domain Name Service / Server / System
- DPI - Dots Per Inch
- DOS - Disk Operating System
- DoS - Denial of Service (View)
- DRAM - Dynamic RAM
- DSDD - Double Sided Double Density
- DSHD - Double Sided High Density
- DSI - Data System International
- DSU - Data Service Unit
- DTH - Direct To Home
- DTSS - Dartmouth Time Sharing System
- DVD - Digital Versatile Disc
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