- C2C - Consume to Consumer
- CAD - Computer Aided Design
- CAE - Computer Aided Engineering
- CAI - Computer Aided Instruction
- CAL - Computer Aided Learning
- CAM - Computer Aided Manufacturing
- CAN - Campus Area Network
- CAT - Computer Aided Training
- CAT - Computerized Axial Tomography
- CAVE - Cellular Authentication and Voice Encryption
- CBE - Computer Based Education
- CBT - Computer Based Training
- CCD - Charge-Coupled Device
- CCTV - Closed Circuit Television
- CD - Compact Disc
- CDMA - Code Division Multiple Access
- CD-ROM – Compact Disc Read Only Memory
- CD-RW - Compact Disc Re-Writable
- CERN - Conseil Européen pour la Recherche Nucléaire (European Organization for Nuclear Research)
- CGA - Colored Graphics Adapter
- CGI - Common Gateway Interface
- CLD - Country Level Domain
- CMOS - Complementary Metal Oxide Semiconductor
- COBOL - Common Business Oriented Language
- CODASYL - Conference On Data System Languages
- COM - Computer Program for Microcomputer
- CPAV - Central Point Anti Virus
- CP/M - Computer Program for Microfilm
- CPI - Character Per Inch
- CPU - Central Processing Unit
- CRT - Cathode Ray Tube
- CSMA - Carrier Sense Multiple Access
- CSS - Cascading Style Sheet
- CSU - Channel Service Unit
- CU - Control Unit
- CUI -Character (Command) User Interface
- CVT - Continuously Variable Transmission
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